Conversations Unplugged

with Don Moxley

Join STEMREGEN Founder and Chief Science Officer, Christian Drapeau, in a dynamic conversation with Don Moxley, an exercise physiologist and longevity expert. In this episode of "Conversations Unplugged," they discuss the importance of autophagy, the role of spermidine in cellular health, and how lifestyle choices can extend both lifespan and healthspan.

Don Moxley

In this episode, Christian Drapeau interviews Don Moxley, a seasoned exercise physiologist who transitioned from the world of athletic performance and research to focus on the science of longevity. Don shares his background in sports science, particularly his work with the Ohio State wrestling team and how his passion for human performance led him to explore the critical role of autophagy—the body’s process of cleaning out damaged cells—in extending healthspan.

Don introduces the concept of spermidine, a naturally occurring molecule that plays a key role in the autophagy process. He explains how spermidine deficiency, exacerbated by modern industrial food production, can lead to a decrease in autophagy, thereby increasing the risk of inflammation-related diseases like cancer, diabetes, and other age-related conditions. Don emphasizes the need for spermidine-rich diets or supplementation to promote cellular cleaning and maintain vitality as we age.

The conversation also explores the relationship between autophagy, exercise, and fasting, which are natural ways to stimulate the body’s cellular cleaning process. Don shares insights from his research, highlighting the importance of maintaining autophagy to prevent the onset of morbidity and ensure a healthier, more active life in the later years.

This episode provides valuable takeaways for anyone looking to improve their longevity and healthspan, with practical advice on incorporating spermidine, exercise, and other lifestyle practices into daily life to optimize cellular health and reduce the risk of chronic diseases.